Isaiah speaks to the internal divisions and conflicts among the tribes of Israel, particularly between Manasseh and Ephraim, who are both part of the Northern Kingdom. This strife is emblematic of the larger issues facing the nation, as these tribes, instead of uniting against common challenges, turn against each other and ultimately against Judah. This internal discord is a reflection of the spiritual and moral decay that has taken root among the people.
Despite these conflicts, God's anger remains, indicating that the people have not yet turned back to Him in repentance. The imagery of God's hand being "still upraised" suggests that His judgment is ongoing and that there is still an opportunity for the people to change their ways. This verse serves as a powerful reminder of the importance of unity and faithfulness among God's people. It calls for introspection and a return to righteousness to restore harmony and avert further divine judgment. The message is timeless, urging believers to seek reconciliation and to align their lives with God's will.