Acts 4:25 reflects on the divine inspiration of scripture, acknowledging that God communicates through His chosen servants, such as David. The verse quotes a passage from the Psalms, illustrating how the Holy Spirit spoke through David. The rhetorical question about nations raging and plotting in vain underscores the futility of opposing God's will. It serves as a reminder that no matter how tumultuous the world may seem, God's plans are steadfast and unchangeable.
This verse is part of a prayer by the early Christian community, who faced opposition and persecution. By invoking this scripture, they express confidence in God's ultimate authority and the certainty that human efforts against His will are ultimately futile. It encourages believers to trust in God's sovereignty, knowing that His purposes will prevail despite any earthly challenges. This assurance is a source of comfort and strength, reminding Christians that God's word is powerful and enduring, and that His plans cannot be thwarted by human schemes.